Lionel Messi, Erling Braut Haaland and Marcus Rashford are all aiming to stay their scoring streaks going whilst Timo Werner is hoping to finish an peculiar series.
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Wednesday fixtures (click on for are living build-up)*
Group E: Sevilla vs Krasnodar
Group E: Chelsea vs Rennes
Group F: Zenit vs Lazio (18.55 CET)
Group F: Club Brugge vs Dortmund
Group G: Barcelona vs Dynamo Kyiv
Group G: Ferencváros vs Juventus
Group H: Başakşehir vs Manchester United (18:55 CET)
Group H: Leipzig vs Paris