Holders Sevilla, 2009 winners Shakhtar Donetsk and Spanish Liga top-four contenders Villarreal all picked up quarter-final first-leg victories on Thursday.
The only game that finished without a winner came in the opening instalment of arguably the tie of the round. Jürgen Klopp’s return to Borussia Dortmund with Liverpool ended in a 1-1 draw, Mats Hummels’ header cancelling out Divock Origi’s first-half opener for the Reds.